After writing the script for El Mariachi, Robert Rodriguez was determined to make the film. Unfortunately, he had no money. Undeterred, Rodriguez signed up for several experimental drug studies and was able to cover most of the film's $7,000 budget with the money he earned.
[Among the drugs tested on Rodriguez was a "speed healer." Years later, he still had divots in his arms where tissues had been removed. Rodriguez later wrote a book (Rebel Without A Crew) about the making of the film.]