While campaiging for the Vice Presidency in 1988, Dan Quayle, famed for his verbal bloopers, was repeatedly asked about his parents' involvement in the extremely right-wing John Birch Society.
"Let me say it one more time," he finally erupted. "It is ill-rel-e-vant!"
["George W. Bush's Secret Service name is 'Tumbler,'" Conan O'Brien once declared. "That's because 'Bumbler' was already taken by Dan Quayle."]